Chronic Myelogenous Leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.

CML is a clonal bone marrow stem cell disorder in which a proliferation of mature granulocytes (neutrophils, eosinophils and basophils) and their precursors is found. It is a type of myeloproliferative neoplasm associated with a characteristic chromosomal translocation called the Philadelphia chromosome.

Diagnosis of CML: –

A small, hypolobated megakaryocyte (center of field) in a bone marrow aspirate, characteristic of chronic myeloid leukemia.

CML is often suspected on the basis of a complete blood count, which shows increased granulocytes of all types, typically including mature myeloid cells. Basophils and eosinophils are almost universally increased; this feature may help differentiate CML from a leukemoid reaction. A bone marrow biopsy is often performed as part of the evaluation for CML, and CML is diagnosed by cytogenetics that detects the translocation which involves the ABL1 gene in chromosome 9 and the BCR gene in chromosome 22. Thus, this abnormality can be detected by routine cytogenetics, and the involved genes BCR-ABL1 can be detected by fluorescent in situ hybridization, as well as by PCR

CML must be distinguished from a leukemoid reaction, which can have a similar appearance on a blood smear

Case Details – 
This is a case of a 32 year old man who came with v high values of BCR ABL – 0.528 indicative of a confirmed case of CML . the Homeopathy treatment was started in Dec 2019.

the value of CANCER indicative was checked again in June 2020 and it had reduced to 0.018 from 0.518 which is a remarkably progress for the patient.

the patient continued medicines and the latest report of the BCR ABL value stands at 0.0046 as tested on on 23rd Dec 2020 🙂

so happy ! All thanks to Sri Krishna